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Bilastine (Beltas) is indicated for the symptomatic treatment of:
✔ Allergic rhino-conjunctivitis (Seasonal & Perennial)
✔ Urticaria (Hives)
✔ Hay fever symptoms – Sneezing, itchy/runny nose, nasal congestion, red & watery eyes
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✅ Description:
Bilastine is a potent, non-sedating, long-acting H1-antihistamine with a high affinity for H1 receptors:
✔ 3x higher than Cetirizine
✔ 5x higher than Fexofenadine
🔹 Selectivity & Safety:
- Does not affect muscarinic, serotonergic, dopaminergic, noradrenergic, or other histamine receptor subtypes (H2, H3, H4)
- No metabolic activation is required for efficacy
- Eliminated 66.35% via feces (non-systemic) & 28.31% via urine (systemic)
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Dosage & Administration
✔ Adults & Adolescents (12+ years):
- 20 mg tablet once daily (for allergic rhinitis, urticaria, allergic rhinoconjunctivitis)
- Take on an empty stomach with water (optimal absorption)
- If a dose is missed, take the next scheduled dose. Do not take an extra dose.
✔ Children (6 to 11 years):
- 10 mg mouth-dissolving tablet once daily
- Can be placed directly in the mouth or dissolved in a teaspoon of water
- Maximum daily dose: 10 mg
✔ Children (2 to 5 years):
- 4 ml oral solution once daily
⚠ Not recommended for children under 2 years due to insufficient safety data.
✔️ Side Effects
- Headache, dizziness
- Somnolence, fatigue
✔️ DrugInteractions
✔ Increased Bilastine levels with:
- Ketoconazole, Erythromycin, Cyclosporine, Diltiazem
- However, no safety concerns were noted
✔ No enhanced CNS depression with:
- Alcohol (20 mg Bilastine) – Similar psychomotor effects as placebo
- Lorazepam (3 mg for 8 days) – No increased sedation
✔️ Contraindications
🚫 Bilastine is contraindicated in patients with hypersensitivity to the drug or its excipients.
✔️ Pregnancy & Lactation
✔ Pregnancy: Limited human data; animal studies show no harm. Use only if necessary.
✔ Lactation: Unknown if excreted in breast milk; caution advised.
✔️ Overdose Effects
✔ Safe in high doses (up to 220 mg single dose or 200 mg/day for 7 days).
✔ Common overdose symptoms:
- Dizziness, headache, nausea
✔ No serious adverse events or QTc prolongation reported.
✔️ Precautions & Warnings
⚠ Driving & Machinery: Generally safe, but rare cases of drowsiness may occur.
⚠ Elderly (65+ years): No difference in safety/efficacy compared to younger patients.
⚠ Renal Impairment: No dose adjustment is needed (Bilastine is not metabolized).
⚠ Liver Impairment: No significant effect on elimination, so dose adjustment is not required.
✔️ Storage Conditions
✅ Store below 30°C, in a cool, dry place, away from light and moisture.
✅ Keep out of reach of children.
